“These are remarkable compounds, with I think remarkable implications, if we can understand how they work and why they work,” says Roland Griffiths, a scientist at Johns Hopkins University, where some of the world’s leading psychedelic research is taking place.

 

Psilocybin mushrooms provoke mystical experiences and spiritual journeys when the body breaks the chemical down into a compound that is very similar to serotonin, a natural neurotransmitter in the brain. But psilocybin and serotonin aren’t exactly the same, explains Robin Carhart-Harris of the Imperial College London, and “that subtle difference in its pharmacology confers profound effects on consciousness.”

 

“What seems to happen in the psychedelic state is that when something is positive, it has the potential to be incredibly positive, to the extent of being euphoric, or ecstatic,” Carhart-Harris says. “But similarly if something is negative, it has the potential to be quite hellish and dysphoric and frightening.”

 

Griffith led a study published in 2006 in which volunteers received psilocybin or a comparative drug and were allowed to relax with soothing music in the presence of people with whom they had a trusting relationship.

 

Psilocybin mushrooms have helped human beings unlock their egos for centuries. This video, Psychedelic Science: Psilocybin by Reason TV, features interviews with two leading researchers who explain what we know about the magic mushroom effect and how much more we have to learn.

 

 


Our videos describing different aspects of what we do.

How Do Psychedelic Drugs Work On The Brain? (Full Lecture)

Comeback of psychedelics in science and medicine: Robin Carhart Harris

Can Magic Mushrooms treat depression?- Robin Carhart-Harris at New Scientist Live 2017

Mendel Kaelen: Psychological & Neurophysiological Effects of Music in Combination with Psychedelics

EXCLUSIVE: Could magic mushrooms treat depression? BBC Newsnight

  • Robert Kew on Help us treat depression!Hi. I would very much like to participate in a trial. I'm 49 and have suffered most of my life with anxiety and depression. I'm currently on dual reuptake inhibitors but they have limited effect for me. I've tried many, many things over the years to…
  • Patryk on The administration of psilocybin to healthy hallucinogen experienced volunteersHello everyone I'm on antidepressant from couple of years and I try many different types. Right now I have worst time ever. I try mushrooms which one found my self on last season 2016. I have found but that was very difficult for me. I go nearly ever…
  • terry hall on Help us treat depression!I would be very interested to hear about your research on your use of psychedelics , I would be very interested if you are looking for new volunteers for further trials , I am 50 years old and I have suffered with depression for 25 years and have fou…
  • Bob on The administration of psilocybin to healthy hallucinogen experienced volunteersHi, I have read your articles and I am currently on anti depressants. I have tried different kinds as I have mild PTSD from military service and suffer from depression constantly. I would very much like to assist and be a volunteer for future trials.
  • Chris noton on The administration of psilocybin to healthy hallucinogen experienced volunteersHello, I’m am 43 year old male living in oxford and suffered from depression and anxiety for 20 some years and I am a chronic suffer. I am very interested in participating on this type of drug trial. In my 20’s I have picked my own mushrooms once or…
  • Anonymous on Are you having a psychedelic experience in the near future?Hi All, I suffer from depression and anxiety and have done so for many years. After being placed on anti-depressants (again), I had a very bad response and the side effects of increased suicidal thoughts became unbearable. It was an everyday battle o…
  • J Moran on Help us treat depression!Hello, I am wondering if you have completed your research into the use of psychedelics to aid with depression. I suffer with it myself and want to know if you are still looking for volunteers? I am currently 20 years old, turning 21 in September. I a…
  • Leo Tognetti on The administration of psilocybin to healthy hallucinogen experienced volunteersHi Drew Thanks for sharing. What was your method?

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