Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms

This study was approved by the National Research Ethics Service (NRES) committee London – West London and was conducted in accordance with the revised declaration of Helsinki (2000), the International Committee on Harmonisation Good Clinical Practice (GCP) guidelines and National Health Service (NHS) Research Governance Framework. Imperial College London sponsored the research which was conducted …

Read morePsilocybin for treatment-resistant depression: fMRI-measured brain mechanisms

Psychedelic medicine: the potential, the people, the politics

Trippy treatment James Worrell/Getty By Sean O’Neill It was quite a comedown in the 1970s when research into psychedelic medicine was virtually shut down in the West. Many countries were beginning to classify psychedelics as “schedule 1”, making them illegal, on the grounds that they were drugs of “abuse” with no agreed-upon medical use. The …

Read morePsychedelic medicine: the potential, the people, the politics

Neural correlates of the LSD experience revealed by multimodal neuroimaging

Lysergic acid diethylamide (LSD) is the prototypical psychedelic drug, but its effects on the human brain have never been studied before with modern neuroimaging. Here, three complementary neuroimag-ing techniques: arterial spin labeling (ASL), blood oxygen level- dependent (BOLD) measures, and magnetoencephalography (MEG), implemented during resting state conditions, revealed marked changes in brain activity after LSD …

Read moreNeural correlates of the LSD experience revealed by multimodal neuroimaging