Twelve people with moderate to severe treatment-resistant depression who had not responded to at least two courses of antidepressants were recruited (six men and six women, aged 30 to 64). Most of the participants actively volunteered to take part following presentations by the researchers and media coverage.
Hallucinogenics such as psilocybin can cause unpleasant reactions, including anxiety and paranoia, so it is important to establish whether the drug can be administered safely to people with depression. To investigate the safety and feasibility of using psilocybin for treatment-resistant depression, researchers from Imperial conducted a strictly monitored feasibility study. As this was not a randomised-controlled trial, the patients knew they were receiving the drug and there was no control group to provide comparison either with existing treatments or with no treatment at all.
Previous studies have looked into the potential of using psychedelic drugs for conditions such as end of life anxiety, obsessive-compulsive disorder and smoking dependence. Psilocybin acts on the serotonin system suggesting it could be developed for use in the treatment of depression.
It is estimated that 350 million people worldwide are affected by depression. The annual cost of depression in England is thought to be around £7.5 billion. Most people with depression respond positively to treatment using antidepressant medication and cognitive behavioural therapy. But around 20 per cent of those with depression do not respond to treatments and are classified as having treatment-resistant depression.
The study team, from Imperial College London, say this could pave the way for future randomised-controlled trials to establish the efficacy of the compound in treating this form of depression.
Our videos describing different aspects of what we do.
Mendel Kaelen: Psychological & Neurophysiological Effects of Music in Combination with Psychedelics
Mendel Kaelen 29th June 2016
Robin Carhart-Harris - Psychedelic drugs in science and medicine
EXCLUSIVE: Could magic mushrooms treat depression? BBC Newsnight
How Do Psychedelic Drugs Work On The Brain? (Full Lecture)
- on Help us treat depression! Hi. I would very much like to participate in a trial. I'm 49 and have suffered most of my life with anxiety and depression. I'm currently on dual reuptake inhibitors but they have limited effect for me. I've tried many, many things over the years to…
- on The administration of psilocybin to healthy hallucinogen experienced volunteers Hello everyone I'm on antidepressant from couple of years and I try many different types. Right now I have worst time ever. I try mushrooms which one found my self on last season 2016. I have found but that was very difficult for me. I go nearly ever…
- on Help us treat depression! I would be very interested to hear about your research on your use of psychedelics , I would be very interested if you are looking for new volunteers for further trials , I am 50 years old and I have suffered with depression for 25 years and have fou…
- on The administration of psilocybin to healthy hallucinogen experienced volunteers Hi, I have read your articles and I am currently on anti depressants. I have tried different kinds as I have mild PTSD from military service and suffer from depression constantly. I would very much like to assist and be a volunteer for future trials.
- on The administration of psilocybin to healthy hallucinogen experienced volunteers Hello, I’m am 43 year old male living in oxford and suffered from depression and anxiety for 20 some years and I am a chronic suffer. I am very interested in participating on this type of drug trial. In my 20’s I have picked my own mushrooms once or…
- on Are you having a psychedelic experience in the near future? Hi All, I suffer from depression and anxiety and have done so for many years. After being placed on anti-depressants (again), I had a very bad response and the side effects of increased suicidal thoughts became unbearable. It was an everyday battle o…
- on Help us treat depression! Hello, I am wondering if you have completed your research into the use of psychedelics to aid with depression. I suffer with it myself and want to know if you are still looking for volunteers? I am currently 20 years old, turning 21 in September. I a…
- on The administration of psilocybin to healthy hallucinogen experienced volunteers Hi Drew Thanks for sharing. What was your method?