Psilocybin frees the brain from its rigid patterns and ego-driven assumptions, and allows the user to look at the world — and him or herself — from a whole new perspective. Many mushroom experiences also are accompanied by waves of good feelings and psychedelic visions of sound and color.


These results build on other evidence about how psilocybin can rewire the brain. A previous study at the Imperial College London showed that brain activity diminished in certain areas when subjects took the substance, particularly in the part of the brain responsible for a sense of self.


“I was fascinated to see similarities between the pattern of brain activity in a psychedelic state and the pattern of brain activity during dream sleep,” lead researcher Robin Carhart-Harris said in a statement. “People often describe taking psilocybin as producing a dreamlike state and our findings have, for the first time, provided a physical representation for the experience in the brain.”


“We find that the psychedelic state is associated with a less constrained and more intercommunicative mode of brain function,” the study concludes, “which is consistent with descriptions of the nature of consciousness in the psychedelic state.”


Magic mushrooms got their name for a reason. Psilocybin — the active chemical in so-called “magic mushrooms” — works on the mind in amazing ways to breed new insights and break from negativity and intransigence.



Our videos describing different aspects of what we do.

Can Magic Mushrooms treat depression?- Robin Carhart-Harris at New Scientist Live 2017

Robin Carhart Harris 20th July 2016

Comeback of psychedelics in science and medicine: Robin Carhart Harris

Psychedelics: Lifting the veil | Robin Carhart-Harris | TEDxWarwick

Can Magic Mushrooms Unlock Depression? | Rosalind Watts | TEDxOxford

Recent Comments

  • Robert Kew on Help us treat depression!Hi. I would very much like to participate in a trial. I'm 49 and have suffered most of my life with anxiety and depression. I'm currently on dual reuptake inhibitors but they have limited effect for me. I've tried many, many things over the years to…
  • Patryk on The administration of psilocybin to healthy hallucinogen experienced volunteersHello everyone I'm on antidepressant from couple of years and I try many different types. Right now I have worst time ever. I try mushrooms which one found my self on last season 2016. I have found but that was very difficult for me. I go nearly ever…
  • terry hall on Help us treat depression!I would be very interested to hear about your research on your use of psychedelics , I would be very interested if you are looking for new volunteers for further trials , I am 50 years old and I have suffered with depression for 25 years and have fou…
  • Bob on The administration of psilocybin to healthy hallucinogen experienced volunteersHi, I have read your articles and I am currently on anti depressants. I have tried different kinds as I have mild PTSD from military service and suffer from depression constantly. I would very much like to assist and be a volunteer for future trials.
  • Chris noton on The administration of psilocybin to healthy hallucinogen experienced volunteersHello, I’m am 43 year old male living in oxford and suffered from depression and anxiety for 20 some years and I am a chronic suffer. I am very interested in participating on this type of drug trial. In my 20’s I have picked my own mushrooms once or…
  • Anonymous on Are you having a psychedelic experience in the near future?Hi All, I suffer from depression and anxiety and have done so for many years. After being placed on anti-depressants (again), I had a very bad response and the side effects of increased suicidal thoughts became unbearable. It was an everyday battle o…
  • J Moran on Help us treat depression!Hello, I am wondering if you have completed your research into the use of psychedelics to aid with depression. I suffer with it myself and want to know if you are still looking for volunteers? I am currently 20 years old, turning 21 in September. I a…
  • Leo Tognetti on The administration of psilocybin to healthy hallucinogen experienced volunteersHi Drew Thanks for sharing. What was your method?

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How Psilocybin Improves Your Brain
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One thought on “How Psilocybin Improves Your Brain

  • November 2, 2015 at 12:09 pm

    Dear Psychedelic Research,

    I am extremely interested in your work as I believe it holds enormous potential for the future treatment of mental health issues, which are becoming more and more prevalent. Speaking from first-hand experience, I very passionately believe that the focus of psychedelic research on mental health issues should be widened to embrace the profoundly positive effect psilocybin can have in the treatment of anxiety AS WELL AS depression.

    I myself suffered from work-related anxiety for several years. Over this period, the anxiety became progressively worse and more psychologically debilitating. It reached a point where my heart would start racing uncontrollably every time my mobile phone rang as I immediately expected it to be someone from work with horrible news or unreasonable demands. This also started happening every time I would login to my emails as I would dread finding some terrible message. The panic and anxiety became absolutely intolerable and I am convinced I was on the point of a total nervous breakdown. To try and cope, I started abusing alcohol just to get to sleep and stop my mind racing.

    Fortunately, I managed to have some time out from work and during this period of convalescence, I took psilocybin. The drug definitely ‘rewired’ my brain in terms of enabling me to see my life and work from a whole new, heightened perspective. The drug highlighted unhealthy thinking habits which had become ingrained over time like stuck records. The drug enabled me to lift the needle off these ‘stuck records’ of thought processes, take the bad vinyl off the turntable and shatter these records into a thousand pieces never to be replayed!

    With the benefit of these new insights, I have re-evaluated my life, changed work and found a deeper level of happiness, contentment and serenity than I ever imagined possible,,, all thanks to psilocybin. I truly hope others can be healed like I was by this miraculous drug.

    Please consider the message of my email, which is that anxiety should also be studied in relation to psilocybin and not just depression.

    Yours sincerely,
    Matthew Turner


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