Decoding the Tripping Brain

Decoding the Tripping Brain

© SEAN MCCABE Lying in a room at Imperial College London, surrounded by low lighting and music, Kirk experienced a vivid recollection of visiting his sick mother before she passed away. “I used to go and see my mum in the hospital quite a lot,” recalls Kirk, a middle-aged computer technician who lives in London […]

MDMA on subjective and BOLD-fMRI responses to autobiographical memories

MDMA on subjective and BOLD-fMRI responses to autobiographical memories

The effect of acutely administered MDMA on subjective and BOLD-fMRI responses to favourite and worst autobiographical memories 3,4-methylenedioxymethamphetamine (MDMA) is a potent monoamine-releaser that is widely used as a recreational drug. Preliminary work has supported the potential of MDMA in psychotherapy for post-traumatic stress disorder (PTSD). The neurobiological mechanisms underlying its putative efficacy are, however, […]

LSD enhances the emotional response to music

LSD enhances the emotional response to music

Rationale There is renewed interest in the therapeutic potential of psychedelic drugs such as lysergic acid diethylamide LSD). LSD was used extensively in the 1950s and 1960s as an adjunct in psychotherapy, reportedly enhancing emotionality. Music is an effective tool to evoke and study emotion and is considered an important element in psychedelic-assisted psychotherapy; however, […]

Implications for psychedelic assisted psychotherapy

Implications for psychedelic assisted psychotherapy

magnetic resonance imaging study with psilocybin – Implications for psychedelic-assisted psychotherapy: functional Background Psilocybin is a classic psychedelic drug that has a history of use in psychotherapy. One of the rationales for its use was that it aids emotional insight by lowering psychological defences. Aims To test the hypothesis that psilocybin facilitates access to personal […]