Neural correlates of the LSD experience revealed by multimodal neuroimaging

Neural correlates of the LSD experience revealed by multimodal neuroimaging

Lysergic acid diethylamide (LSD) is the prototypical psychedelic drug, but its effects on the human brain have never been studied before with modern neuroimaging. Here, three complementary neuroimag-ing techniques: arterial spin labeling (ASL), blood oxygen level- dependent (BOLD) measures, and magnetoencephalography (MEG), implemented during resting state conditions, revealed marked changes in brain activity after LSD […]

The effects of psilocybin and MDMA on between-network resting state functional connectivity

The effects of psilocybin and MDMA on between-network resting state functional connectivity

The effects of psilocybin and MDMA on between-network resting state functional connectivity in healthy volunteers Perturbing a system and observing the consequences is a classic scientific strategy for understanding a phenomenon. Psychedelic drugs perturb consciousness in a marked and novel way and thus are powerful tools for studying its mechanisms. In the present analysis, we […]

How Psilocybin Improves Your Brain

How Psilocybin Improves Your Brain

Psilocybin frees the brain from its rigid patterns and ego-driven assumptions, and allows the user to look at the world — and him or herself — from a whole new perspective. Many mushroom experiences also are accompanied by waves of good feelings and psychedelic visions of sound and color.   These results build on other […]

The Magic Effect Of Psilocybin Mushrooms

The Magic Effect Of Psilocybin Mushrooms

“These are remarkable compounds, with I think remarkable implications, if we can understand how they work and why they work,” says Roland Griffiths, a scientist at Johns Hopkins University, where some of the world’s leading psychedelic research is taking place.   Psilocybin mushrooms provoke mystical experiences and spiritual journeys when the body breaks the chemical […]

The administration of psilocybin to healthy hallucinogen experienced volunteers

The administration of psilocybin to healthy hallucinogen experienced volunteers

The administration of psilocybin to healthy,hallucinogen-experienced volunteers in a mock-functional magnetic resonance imaging environment: a preliminary investigation of tolerability This study sought to assess the tolerability of intravenously administered psilocybin in healthy, hallucinogen-experienced volunteers in a mock-magnetic resonance imaging environment as a preliminary stage to a controlled investigation using functional magnetic resonance imaging to explore […]

Broadband Cortical Desynchronization Underlies Psychedelic State

Broadband Cortical Desynchronization Underlies Psychedelic State

Broadband Cortical Desynchronization Underlies the Human Psychedelic State   Psychedelic drugs produce profound changes in consciousness, but the underlying neurobiological mechanisms for this remain unclear. Spontaneous and induced oscillatory activity was recorded in healthy human participants with magnetoencephalography after intravenous infusion of psilocybin—prodrug of the nonselective serotonin 2A receptor agonist and classic psychedelic psilocin. Psilocybin […]

LSD enhances the emotional response to music

LSD enhances the emotional response to music

Rationale There is renewed interest in the therapeutic potential of psychedelic drugs such as lysergic acid diethylamide LSD). LSD was used extensively in the 1950s and 1960s as an adjunct in psychotherapy, reportedly enhancing emotionality. Music is an effective tool to evoke and study emotion and is considered an important element in psychedelic-assisted psychotherapy; however, […]

Implications for psychedelic assisted psychotherapy

Implications for psychedelic assisted psychotherapy

magnetic resonance imaging study with psilocybin – Implications for psychedelic-assisted psychotherapy: functional Background Psilocybin is a classic psychedelic drug that has a history of use in psychotherapy. One of the rationales for its use was that it aids emotional insight by lowering psychological defences. Aims To test the hypothesis that psilocybin facilitates access to personal […]

Psychedelic drugs should be legally reclassified

Psychedelic drugs should be legally reclassified

Psychedelic drugs should be legally reclassified so that researchers can investigate their therapeutic potential Trials of physiologically safe and non-addictive drugs such as LSD are almost impossible, writes James J H Rucker, calling on the authorities to downgrade their unnecessarily restrictive class A, schedule 1 classification James J H Rucker specialist registrar in adult psychiatry […]