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Ask a healthy person who’s tripped on psychedelics what it felt like, and they’ll probably tell you they saw sounds or heard colors: The crash-bang of a dropped box took on an aggressive,dark shape. A bright green light seemed to emit a piercing, high-pitched screech. In actuality, this “cross-wiring” — synaesthesia, as it’s known scientifically — may … Read more
Twelve people with moderate to severe treatment-resistant depression who had not responded to at least two courses of antidepressants were recruited (six men and six women, aged 30 to 64). Most of the participants actively volunteered to take part following presentations by the researchers and media coverage. Hallucinogenics such as psilocybin can cause unpleasant reactions, … Read more
The intensity of the effects reported by the participants, including visions of geometric patterns, unusual bodily sensations and altered sense of space and time, correlated with a decrease in oxygenation and blood flow in certain parts of the brain. Professor David Nutt, from the Department of Medicine at Imperial College London, the senior author of both studies, … Read more
“The knock-on effect is this profound impairment of research. We are the first people ever to have done a psilocybin study in the UK, but we are still hunting for a company that can manufacture the drug to GMP standards for the clinical trial, even though we’ve been trying for a year to find one. … Read more
Lysergic acid diethylamide (LSD) is the prototypical psychedelic drug, but its effects on the human brain have never been studied before with modern neuroimaging. Here, three complementary neuroimag-ing techniques: arterial spin labeling (ASL), blood oxygen level- dependent (BOLD) measures, and magnetoencephalography (MEG), implemented during resting state conditions, revealed marked changes in brain activity after LSD … Read more