Psilocybin for treatment-resistant depression

Psilocybin for treatment-resistant depression

Twelve people with moderate to severe treatment-resistant depression who had not responded to at least two courses of antidepressants were recruited (six men and six women, aged 30 to 64). Most of the participants actively volunteered to take part following presentations by the researchers and media coverage. Hallucinogenics such as psilocybin can cause unpleasant reactions, … Read more

Magic mushrooms’ effects illuminated in brain imaging studies

The intensity of the effects reported by the participants, including visions of geometric patterns, unusual bodily sensations and altered sense of space and time, correlated with a decrease in oxygenation and blood flow in certain parts of the brain. Professor David Nutt, from the Department of Medicine at Imperial College London, the senior author of both studies, … Read more

How do hallucinogens work on the brain?

How do hallucinogens  work on the brain?

How do hallucinogens work on the brain? Robin Carhart-Harris, Mendel Kaelen and David Nutt consider a big question on several levels The ‘classic’ hallucinogens – such as LSD (derived from ergotamine found in ergot fungi), dimethyltryptamine (DMT, the major hallucinogenic component of ayahuasca) and psilocybin (from magic mushrooms) – possess a unique and arguably unrivalled … Read more

Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis

Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis  of Early Psychosis

Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis Psilocybin is a classic psychedelic and a candidate drug model of psychosis. This study measured the effects of psilocybin on resting-state network and thalamocortical functional connectivity (FC) using functional magnetic resonance imaging (fMRI). Fifteen healthy volunteers received intravenous infusions of psilocybin and placebo in … Read more