Magic mushrooms trial for depression delayed by red tape

“The knock-on effect is this profound impairment of research. We are the first people ever to have done a psilocybin study in the UK, but we are still hunting for a company that can manufacture the drug to GMP standards for the clinical trial, even though we’ve been trying for a year to find one. …

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How to Pick Music for People on LSD, From a Scientist Whose Job That Is

The idea of incorporating music into psychedelic therapy isn’t new; it was a point of great interest to music therapists in the 60s. But Kaelen is trying to ground it in a solid scientific framework. He explained that the need to include music in these trials is borne directly from the rising interest in studying …

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How do hallucinogens work on the brain?

How do hallucinogens work on the brain? Robin Carhart-Harris, Mendel Kaelen and David Nutt consider a big question on several levels The ‘classic’ hallucinogens – such as LSD (derived from ergotamine found in ergot fungi), dimethyltryptamine (DMT, the major hallucinogenic component of ayahuasca) and psilocybin (from magic mushrooms) – possess a unique and arguably unrivalled …

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Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis

Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis Psilocybin is a classic psychedelic and a candidate drug model of psychosis. This study measured the effects of psilocybin on resting-state network and thalamocortical functional connectivity (FC) using functional magnetic resonance imaging (fMRI). Fifteen healthy volunteers received intravenous infusions of psilocybin and placebo in …

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The effects of psilocybin and MDMA on between-network resting state functional connectivity

The effects of psilocybin and MDMA on between-network resting state functional connectivity in healthy volunteers Perturbing a system and observing the consequences is a classic scientific strategy for understanding a phenomenon. Psychedelic drugs perturb consciousness in a marked and novel way and thus are powerful tools for studying its mechanisms. In the present analysis, we …

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Cause for a re- think on drug models of psychosis and other psychiatric disorders

Psychiatry’s next top model: cause for a re-think on drug models of psychosis and other psychiatric disorders RL Carhart-Harris, S Brugger, DJ Nutt and JM Stone Despite the widespread application of drug modelling in psychiatric research, the relative value of different models has never been formally compared in the same analysis. Here we compared the …

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The administration of psilocybin to healthy hallucinogen experienced volunteers

The administration of psilocybin to healthy,hallucinogen-experienced volunteers in a mock-functional magnetic resonance imaging environment: a preliminary investigation of tolerability This study sought to assess the tolerability of intravenously administered psilocybin in healthy, hallucinogen-experienced volunteers in a mock-magnetic resonance imaging environment as a preliminary stage to a controlled investigation using functional magnetic resonance imaging to explore …

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Neural correlates of the psychedelic state

Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin Psychedelic drugs have a long history of use in healing ceremonies, but despite renewed interest in their therapeutic potential, we continue to know very little about how they work in the brain. Here we used psilocybin, a classic psychedelic found in magic …

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