Psychedelic medicine: the potential, the people, the politics

Trippy treatment James Worrell/Getty By Sean O’Neill It was quite a comedown in the 1970s when research into psychedelic medicine was virtually shut down in the West. Many countries were beginning to classify psychedelics as “schedule 1”, making them illegal, on the grounds that they were drugs of “abuse” with no agreed-upon medical use. The …

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Ecstasy users report different sleep to matched controls

Current and former ecstasy users report different sleep to matched controls: a web-based questionnaire study This study sought to test the association between ecstasy use and abnormal sleep. An anonymous web-based questionnaire containing questions on drug use and sleep was completed by 1035 individuals. From this large sample, a group of 89 ecstasy users were …

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The effects of psilocybin and MDMA on between-network resting state functional connectivity

The effects of psilocybin and MDMA on between-network resting state functional connectivity in healthy volunteers Perturbing a system and observing the consequences is a classic scientific strategy for understanding a phenomenon. Psychedelic drugs perturb consciousness in a marked and novel way and thus are powerful tools for studying its mechanisms. In the present analysis, we …

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A web based survey on mephedrone

A web-based survey on mephedrone Mephedrone (4-methylmethcathinone) is a substituted cathinone with stimulant properties. The popularity of mephedrone in the UK rose sharply in 2009 after it became seen as a legal, cheap and easily available alternative to MDMA (ecstasy). Adverse events associated with its use, including a series of alleged deaths, attracted media attention …

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MDMA on subjective and BOLD-fMRI responses to autobiographical memories

The effect of acutely administered MDMA on subjective and BOLD-fMRI responses to favourite and worst autobiographical memories 3,4-methylenedioxymethamphetamine (MDMA) is a potent monoamine-releaser that is widely used as a recreational drug. Preliminary work has supported the potential of MDMA in psychotherapy for post-traumatic stress disorder (PTSD). The neurobiological mechanisms underlying its putative efficacy are, however, …

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The Effects of Acutely Administered MDMA on Spontaneous Brain Function

The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level–Dependent Resting State Functional Connectivity. Background: The compound 3,4-methylenedioxymethamphetamine (MDMA) is a potent monoamine releaser that produces an acute euphoria in most individuals. Methods: In a double-blind, placebo-controlled, balanced-order study, MDMA was orally administered …

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Equivalent effects of acute tryptophan depletion on REM sleep in ecstasy users

Equivalent effects of acute tryptophan depletion on REM sleep in ecstasy users and controls This study sought to test the association between 3,4-methylenedioxymethamphetamine use, serotonergic function and sleep. Materials and methods Ambulatory polysomnography was used to measure three nights sleep in 12 ecstasy users and 12 controls after screening (no intervention), a tryptophan- free amino …

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