Neural correlates of the LSD experience revealed by multimodal neuroimaging

Neural correlates of the LSD experience revealed by multimodal neuroimaging

Lysergic acid diethylamide (LSD) is the prototypical psychedelic drug, but its effects on the human brain have never been studied before with modern neuroimaging. Here, three complementary neuroimag-ing techniques: arterial spin labeling (ASL), blood oxygen level- dependent (BOLD) measures, and magnetoencephalography (MEG), implemented during resting state conditions, revealed marked changes in brain activity after LSD […]

Was it a vision or a waking dream?

Was it a vision or a waking dream?

Was it a vision or a waking dream? A commentary on Disrupting posterior cingulate connectivity disconnects consciousness from the external environment by Herbet, G., Lafargue, G., de Champfleur, N. M., Moritz-Gasser, S., le Bars, E., Bonnetblanc, F., et al. (2014). Neuropsychologia 56C, 239–244. doi: 10.1016/j.neuropsychologia.2014.01.020 Reminiscent of Wilder Penfield’s famous experiments, Neurologists in France have […]

Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis  of Early Psychosis

Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis

Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis Psilocybin is a classic psychedelic and a candidate drug model of psychosis. This study measured the effects of psilocybin on resting-state network and thalamocortical functional connectivity (FC) using functional magnetic resonance imaging (fMRI). Fifteen healthy volunteers received intravenous infusions of psilocybin and placebo in […]

The Entropic Brain – A theory of conscious states

The Entropic Brain – A theory of conscious states

The Entropic Brain – A theory of conscious states informed by neuroimaging research with psychedelic drugs Entropy is a dimensionless quantity that is used for measuring uncertainty about the state of a system but it can also imply physical qualities, where high entropy is synonymous with high disorder. Entropy is applied here in the context […]

Finding the Self by Losing the Self

Finding the Self by Losing the Self

Finding the Self by Losing the Self: Neural Correlates of Ego-Dissolution Under Psilocybin Ego-disturbances have been a topic in schizophrenia research since the earliest clinical descriptions of the disorder. Manifesting as a feeling that one’s “self,” “ego,” or “I” is disintegrating or that the border between one’s self and the external world is dissolving, “ego-disintegration” […]