Equivalent effects of acute tryptophan depletion on REM sleep in ecstasy users

Equivalent effects of acute tryptophan depletion on REM sleep in ecstasy users and controls This study sought to test the association between 3,4-methylenedioxymethamphetamine use, serotonergic function and sleep. Materials and methods Ambulatory polysomnography was used to measure three nights sleep in 12 ecstasy users and 12 controls after screening (no intervention), a tryptophan- free amino …

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Implications for psychedelic assisted psychotherapy

magnetic resonance imaging study with psilocybin – Implications for psychedelic-assisted psychotherapy: functional Background Psilocybin is a classic psychedelic drug that has a history of use in psychotherapy. One of the rationales for its use was that it aids emotional insight by lowering psychological defences. Aims To test the hypothesis that psilocybin facilitates access to personal …

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Psychedelic drugs should be legally reclassified

Psychedelic drugs should be legally reclassified so that researchers can investigate their therapeutic potential Trials of physiologically safe and non-addictive drugs such as LSD are almost impossible, writes James J H Rucker, calling on the authorities to downgrade their unnecessarily restrictive class A, schedule 1 classification James J H Rucker specialist registrar in adult psychiatry …

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Finding the Self by Losing the Self

Finding the Self by Losing the Self: Neural Correlates of Ego-Dissolution Under Psilocybin Ego-disturbances have been a topic in schizophrenia research since the earliest clinical descriptions of the disorder. Manifesting as a feeling that one’s “self,” “ego,” or “I” is disintegrating or that the border between one’s self and the external world is dissolving, “ego-disintegration” …

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Mourning and melancholia revisited

Mourning and melancholia revisited: correspondences between principles of Freudian metapsychology and empirical findings in neuropsychiatry. Freud began his career as a neurologist studying the anatomy and physiology of the nervous system, but it was his later work in psychology that would secure his place in history. This paper draws attention to consistencies between physiological processes …

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