User perceptions of the benefits and harms of hallucinogenic drug use

User perceptions of the benefits and harms of hallucinogenic drug use

User perceptions of the benefits and harms of hallucinogenic drug use: A web-based questionnaire study   This study used a web-based questionnaire to investigate user perceptions of the benefits and harms of hallucinogenic drug use. Over 600 forms were submitted. Users were asked to comment on the acute and prolonged effects of different drugs and … Read more

Broadband Cortical Desynchronization Underlies Psychedelic State

Broadband Cortical Desynchronization Underlies Psychedelic State

Broadband Cortical Desynchronization Underlies the Human Psychedelic State   Psychedelic drugs produce profound changes in consciousness, but the underlying neurobiological mechanisms for this remain unclear. Spontaneous and induced oscillatory activity was recorded in healthy human participants with magnetoencephalography after intravenous infusion of psilocybin—prodrug of the nonselective serotonin 2A receptor agonist and classic psychedelic psilocin. Psilocybin … Read more

MDMA on subjective and BOLD-fMRI responses to autobiographical memories

MDMA on subjective and BOLD-fMRI responses to autobiographical memories

The effect of acutely administered MDMA on subjective and BOLD-fMRI responses to favourite and worst autobiographical memories 3,4-methylenedioxymethamphetamine (MDMA) is a potent monoamine-releaser that is widely used as a recreational drug. Preliminary work has supported the potential of MDMA in psychotherapy for post-traumatic stress disorder (PTSD). The neurobiological mechanisms underlying its putative efficacy are, however, … Read more