Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis

Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis

Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis Psilocybin is a classic psychedelic and a candidate drug model of psychosis. This study measured the effects of psilocybin on resting-state network and thalamocortical functional connectivity (FC) using functional magnetic resonance imaging (fMRI). Fifteen healthy volunteers received intravenous infusions of psilocybin and placebo in … Read more

The effects of psilocybin and MDMA on between-network resting state functional connectivity

The effects of psilocybin and MDMA on between-network resting state functional connectivity

The effects of psilocybin and MDMA on between-network resting state functional connectivity in healthy volunteers Perturbing a system and observing the consequences is a classic scientific strategy for understanding a phenomenon. Psychedelic drugs perturb consciousness in a marked and novel way and thus are powerful tools for studying its mechanisms. In the present analysis, we … Read more

Cause for a re- think on drug models of psychosis and other psychiatric disorders

Cause for a re- think on drug models of psychosis and other psychiatric disorders

Psychiatry’s next top model: cause for a re-think on drug models of psychosis and other psychiatric disorders RL Carhart-Harris, S Brugger, DJ Nutt and JM Stone Despite the widespread application of drug modelling in psychiatric research, the relative value of different models has never been formally compared in the same analysis. Here we compared the … Read more

The administration of psilocybin to healthy hallucinogen experienced volunteers

The administration of psilocybin to healthy hallucinogen experienced volunteers

The administration of psilocybin to healthy,hallucinogen-experienced volunteers in a mock-functional magnetic resonance imaging environment: a preliminary investigation of tolerability This study sought to assess the tolerability of intravenously administered psilocybin in healthy, hallucinogen-experienced volunteers in a mock-magnetic resonance imaging environment as a preliminary stage to a controlled investigation using functional magnetic resonance imaging to explore … Read more

Homological scaffolds of brain functional networks

Homological scaffolds of brain functional networks

Homological scaffolds of brain functional networks Networks, as efficient representations of complex systems, have appealed to scientists for a long time and now permeate many areas of science, including neuroimaging (Bullmore and Sporns 2009 Nat. Rev. Neurosci. 10, 186–198. (doi:10.1038/nrn2618)). Traditionally, the structure of complex networks has been studied through their statistical properties and metrics … Read more