Magic Mushrooms Could Be the Future of Antidepressants

We spoke to Dr. Mark Bolstridge, a clinical psychiatrist searching for alternative and unusual treatments for depression.

Bolstridge, alongside David Nutt, president of the British Neuroscience Association and former government drugs advisor, initially applied to run a psilocybin trial in 2013. Nutt had previously conducted small experiments before more stringent regulations around psychoactive substances were put into place. He felt that psilocybin had the potential to alleviate symptoms of depression and wanted to carry out further experiments.

Bolstridge is already in the process of searching for alternative and unusual treatments. In particular, he’s been looking into the hallucinogenic compound found within magic mushrooms: psilocybin.

“There are a distinct proportion of patients who don’t get better despite taking lots of different antidepressants,” says Dr. Mark Bolstridge, an honorary research associate at UCL and a clinical psychiatrist. “That’s frustrating as a clinician, that even though we do have a lot of drugs at our disposal, for some people, none of them work.”

found that some drug companies were selectively publishing studies on antidepressants that showed the drugs had a benefit and shelving others that showed there was no overall effect.

, doctors treat the causes in a crude way, with drugs “aimed at the wrong target,” often focusing on reducing stress rather than depression itself. Others have suggested that

The science of antidepressants, is not, as it goes, an exact science. Two patients can react differently to the same drug. For some people, many of the existing drugs won’t have any effect at all.

 

 

List of news articles featuring Lancet Paper Publication

Just a list of news outlets that have featured articles about our paper being published today:

‘Magic mushrooms’ drug could help with depression, trial suggests

How Magic Mushrooms Could Treat Depression

Study Finds Magic Mushrooms Could Treat Severe Depression

Magic mushroom ingredient may ease severe depression, study suggests

‘Magic’ Mushrooms Show Promise Against Depression In First-Ever Trial

Can magic mushrooms dampen depression?

Magic Mushroom Compound Investigated in Treatment-Resistant Depression

Could magic mushrooms help relieve depression?

How ‘Magic Mushroom’ Drugs Could Help Fight Treatment-Resistant Depression

“Magic” Mushroom Compound Eases Depression

They Had Been Depressed for 18 Years. Then They Took Mushrooms

Magic mushroom ingredient offers hope for treating depression

We saw magic mushrooms lift long-term depression. It’s time for a change of perception

We’re finding out more about how a seemingly unlikely drug might one day be used to tackle depression

Magic Mushroom Drug Lifts Depression in Human Trial

The hallucinogenic chemical in magic mushrooms could help treat depression

Magic mushroom drug psilocybin can treat severe depression: study

Magic mushrooms could help treat severe depression

Can magic mushrooms, a hallucinogenic Class A drug, help people with DEPRESSION?

Magic mushroom compound psilocybin could provide new avenue for antidepressant research

Magic mushrooms could cure severe depression – scientists

Clinical trial finds two doses of magic mushrooms can lift severe depression for three weeks

Magic mushrooms lifts severe depression in trial

The Morning Brew: Magic mushrooms lift severe depression in clinical trial

Magic mushrooms could be ‘serious breakthrough’ for depression treatment, claims drugs expert

Magic mushrooms might be able to help people with severe depression

Magic Mushrooms Could Help Fight Depression

Magic mushrooms drug could help treat depression

Magic mushrooms helped drug trial volunteer ‘stay connected’ with his dead mother

Psilocybin for treatment-resistant depression

Magic mushrooms ‘promising’ in depression

OPINION: Mushrooms can treat PTSD and depression

Psilocybin for treatment-resistant depression

Twelve people with moderate to severe treatment-resistant depression who had not responded to at least two courses of antidepressants were recruited (six men and six women, aged 30 to 64). Most of the participants actively volunteered to take part following presentations by the researchers and media coverage. Hallucinogenics such as psilocybin can cause unpleasant reactions, …

Read morePsilocybin for treatment-resistant depression

Magic mushrooms’ effects illuminated in brain imaging studies

The intensity of the effects reported by the participants, including visions of geometric patterns, unusual bodily sensations and altered sense of space and time, correlated with a decrease in oxygenation and blood flow in certain parts of the brain. Professor David Nutt, from the Department of Medicine at Imperial College London, the senior author of both studies, …

Read moreMagic mushrooms’ effects illuminated in brain imaging studies

Magic mushrooms trial for depression delayed by red tape

“The knock-on effect is this profound impairment of research. We are the first people ever to have done a psilocybin study in the UK, but we are still hunting for a company that can manufacture the drug to GMP standards for the clinical trial, even though we’ve been trying for a year to find one. …

Read moreMagic mushrooms trial for depression delayed by red tape

How to Pick Music for People on LSD, From a Scientist Whose Job That Is

The idea of incorporating music into psychedelic therapy isn’t new; it was a point of great interest to music therapists in the 60s. But Kaelen is trying to ground it in a solid scientific framework. He explained that the need to include music in these trials is borne directly from the rising interest in studying …

Read moreHow to Pick Music for People on LSD, From a Scientist Whose Job That Is

Neural correlates of the LSD experience revealed by multimodal neuroimaging

Lysergic acid diethylamide (LSD) is the prototypical psychedelic drug, but its effects on the human brain have never been studied before with modern neuroimaging. Here, three complementary neuroimag-ing techniques: arterial spin labeling (ASL), blood oxygen level- dependent (BOLD) measures, and magnetoencephalography (MEG), implemented during resting state conditions, revealed marked changes in brain activity after LSD …

Read moreNeural correlates of the LSD experience revealed by multimodal neuroimaging