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Patients taking psilocybin to treat depression show reduced symptoms weeks after treatment following a ‘reset’ of their brain activity.

 

 

The findings come from a study in which researchers from Imperial College London used psilocybin – the psychoactive compound that occurs naturally in magic mushrooms – to treat a small number of patients with depression in whom conventional treatment had failed.

In a paper, published in the journal Scientific Reports, the researchers describe patient-reported benefits lasting up to five weeks after treatment, and believe the psychedelic compound may effectively reset the activity of key brain circuits known to play a role in depression.

 

Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms’ by Carhart-Harris, R, et al. is published in the journal Scientific Reports.

Main article image: Carhart-Harris, R, et al. Scientific Reports.
Image one: Magic mushrooms (Shutterstock)
Image two: Robin Carhart-Harris (Imperial College London / Thomas Angus)

Source: Magic mushrooms may ‘reset’ the brains of depressed patients


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  • Patryk on The administration of psilocybin to healthy hallucinogen experienced volunteersHello everyone I'm on antidepressant from couple of years and I try many different types. Right now I have worst time ever. I try mushrooms which one found my self on last season 2016. I have found but that was very difficult for me. I go nearly ever…
  • terry hall on Help us treat depression!I would be very interested to hear about your research on your use of psychedelics , I would be very interested if you are looking for new volunteers for further trials , I am 50 years old and I have suffered with depression for 25 years and have fou…
  • Bob on The administration of psilocybin to healthy hallucinogen experienced volunteersHi, I have read your articles and I am currently on anti depressants. I have tried different kinds as I have mild PTSD from military service and suffer from depression constantly. I would very much like to assist and be a volunteer for future trials.
  • Chris noton on The administration of psilocybin to healthy hallucinogen experienced volunteersHello, I’m am 43 year old male living in oxford and suffered from depression and anxiety for 20 some years and I am a chronic suffer. I am very interested in participating on this type of drug trial. In my 20’s I have picked my own mushrooms once or…
  • Anonymous on Are you having a psychedelic experience in the near future?Hi All, I suffer from depression and anxiety and have done so for many years. After being placed on anti-depressants (again), I had a very bad response and the side effects of increased suicidal thoughts became unbearable. It was an everyday battle o…
  • J Moran on Help us treat depression!Hello, I am wondering if you have completed your research into the use of psychedelics to aid with depression. I suffer with it myself and want to know if you are still looking for volunteers? I am currently 20 years old, turning 21 in September. I a…
  • Leo Tognetti on The administration of psilocybin to healthy hallucinogen experienced volunteersHi Drew Thanks for sharing. What was your method?
  • Richard NAUGHTON on Help us treat depression!These mushrooms have powers beyond the understanding of the modern world that have been lost in translation since the dawn of man . I've used them and felt drawn to them and felt it was a calling . I collected them myself for 15 years ate them , drie…

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Magic mushrooms may ‘reset’ the brains of depressed patients
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