We spoke to Dr. Mark Bolstridge, a clinical psychiatrist searching for alternative and unusual treatments for depression.

Bolstridge, alongside David Nutt, president of the British Neuroscience Association and former government drugs advisor, initially applied to run a psilocybin trial in 2013. Nutt had previously conducted small experiments before more stringent regulations around psychoactive substances were put into place. He felt that psilocybin had the potential to alleviate symptoms of depression and wanted to carry out further experiments.

Bolstridge is already in the process of searching for alternative and unusual treatments. In particular, he’s been looking into the hallucinogenic compound found within magic mushrooms: psilocybin.

“There are a distinct proportion of patients who don’t get better despite taking lots of different antidepressants,” says Dr. Mark Bolstridge, an honorary research associate at UCL and a clinical psychiatrist. “That’s frustrating as a clinician, that even though we do have a lot of drugs at our disposal, for some people, none of them work.”

found that some drug companies were selectively publishing studies on antidepressants that showed the drugs had a benefit and shelving others that showed there was no overall effect.

, doctors treat the causes in a crude way, with drugs “aimed at the wrong target,” often focusing on reducing stress rather than depression itself. Others have suggested that

The science of antidepressants, is not, as it goes, an exact science. Two patients can react differently to the same drug. For some people, many of the existing drugs won’t have any effect at all.

 

 


Our videos describing different aspects of what we do.

Mendel Kaelen: Psychological & Neurophysiological Effects of Music in Combination with Psychedelics

Can Magic Mushrooms Unlock Depression? | Rosalind Watts | TEDxOxford

Robin Carhart-Harris - Psychedelic drugs in science and medicine

Comeback of psychedelics in science and medicine: Robin Carhart Harris

Psychedelics: Lifting the veil | Robin Carhart-Harris | TEDxWarwick

  • Patryk on The administration of psilocybin to healthy hallucinogen experienced volunteersHello everyone I'm on antidepressant from couple of years and I try many different types. Right now I have worst time ever. I try mushrooms which one found my self on last season 2016. I have found but that was very difficult for me. I go nearly ever…
  • terry hall on Help us treat depression!I would be very interested to hear about your research on your use of psychedelics , I would be very interested if you are looking for new volunteers for further trials , I am 50 years old and I have suffered with depression for 25 years and have fou…
  • Bob on The administration of psilocybin to healthy hallucinogen experienced volunteersHi, I have read your articles and I am currently on anti depressants. I have tried different kinds as I have mild PTSD from military service and suffer from depression constantly. I would very much like to assist and be a volunteer for future trials.
  • Chris noton on The administration of psilocybin to healthy hallucinogen experienced volunteersHello, I’m am 43 year old male living in oxford and suffered from depression and anxiety for 20 some years and I am a chronic suffer. I am very interested in participating on this type of drug trial. In my 20’s I have picked my own mushrooms once or…
  • Anonymous on Are you having a psychedelic experience in the near future?Hi All, I suffer from depression and anxiety and have done so for many years. After being placed on anti-depressants (again), I had a very bad response and the side effects of increased suicidal thoughts became unbearable. It was an everyday battle o…
  • J Moran on Help us treat depression!Hello, I am wondering if you have completed your research into the use of psychedelics to aid with depression. I suffer with it myself and want to know if you are still looking for volunteers? I am currently 20 years old, turning 21 in September. I a…
  • Leo Tognetti on The administration of psilocybin to healthy hallucinogen experienced volunteersHi Drew Thanks for sharing. What was your method?
  • Richard NAUGHTON on Help us treat depression!These mushrooms have powers beyond the understanding of the modern world that have been lost in translation since the dawn of man . I've used them and felt drawn to them and felt it was a calling . I collected them myself for 15 years ate them , drie…

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