Help us treat depression!

What is Psychedelic Science Org UK?

Psychedelic science org uk is a crowd-funding campaign that aims to raise funds for scientific research with psychedelic drugs, with a special focus on a clinical trial assessing the safety and efficacy of psilocybin as a treatment for depression.

Psychedelic Science org uk was founded by Dr Robin Carhart-Harris in August 2014. Robin is a psychopharmacologist working at Imperial College London in the Centre for Neuropsychopharmacology, on scientific research with psychedelic drugs. Professor David Nutt is the Edmond J Safra Chair in Neuropsychopharmacology at Imperial College London. David and Robin have been working with Amanda Feilding, Director of the Beckley Foundation, carrying out pioneering brain-imaging research with psychedelic drugs, such as psilocybin (magic mushrooms), MDMA and LSD, as part of the Beckley Foundation/Imperial College Psychopharmacological Research Programme.

 

Why does this matter?

Depression is a serious global problem. It’s the leading cause of disability worldwide, is linked to over half of all suicides, and affects some 350 million people. Worse still, the prevalence of depression is increasing; the World Health Organisation estimates that depression will become the leading overall contributor to the global burden of disease by 2030.

Mental health research is seriously under-funded, especially when compared with other major illnesses such as cancer and heart disease and so the funding that is available for depression research isn’t in any way proportional to the size of the problem.

Depression is also extremely difficult to treat. Around half of patients with depression do not respond to treatment with antidepressant medication and these medications, while effective in some patients, are associated with side-effects and need to be taken daily. Worse still, up to 20% of people do not respond to any treatment at all and this leaves them isolated and with little hope. Options for severe depression are limited and include such things as electroconvulsive therapy (ECT) and more aggressive medication strategies. Our psilocybin research is focused on helping this group of ‘treatment resistant’ patients by offering an alternative option for their depression.

 

Why might psilocybin be helpful?

Psilocybin occurring naturally in certain mushroom species has been used for millennia by some cultures for healing purposes but Western medicine only became privy to the therapeutic potential of psilocybin in the late 1950s when the Swiss chemist Albert Hofmann identified it as the major psychoactive ingredient of ‘magic mushrooms’. Thereafter, for a period of about 10 years, psilocybin was used in psychotherapy for the treatment of various psychiatric disorders including depression. The results of this work were extremely promising, with some psychiatrists heralding psychedelics as breakthrough medicines with immense scientific and therapeutic potential. Indeed, one even declared that: “Psychedelics could be for psychiatry what the microscope is for biology or the telescope for astronomy.” (Stan Grof, 1975)

Regrettably, a conservative backlash on psychedelics occurred in the late 1960s, fuelled by escalating recreational use and a surrounding hysteria stoked by sensationalistic media reporting. These events led to the cessation of legitimate scientific and clinical research with psychedelics and this effective prohibition on psychedelic science lasted for several decades.

Thankfully, clinical research with psychedelics is currently experiencing somewhat of a renaissance. Recent pilot studies in the US have suggested that psilocybin-assisted psychotherapy may be effective for treating obsessive compulsive, anxiety related to dying and depression. Other research teams have been looking at the potential of psilocybin to treat alcohol and tobacco dependence, with very promising preliminary results and one particularly impressive study found that just a single experience with psilocybin improved well-being and life satisfaction for well over one year in two thirds of their study participants.

At Imperial College, our own research has focused on the brain effects of psychedelics, using cutting-edge brain imaging techniques such as fMRI and MEG. In 2012, we published a paper reporting that psilocybin changes brain activity in a manner that is consistent with a large range of effective treatments for depression. More specifically, we found that circuits that are over-active and reinforced in depression become loosened and normalised under psilocybin. Briefly, psilocybin works on the serotonin system. Serotonin is a chemical messenger in the brain that is linked to the regulation of mood. Broadly speaking, increased serotonin signalling is associated with elevated mood, and psilocybin (which, molecularly, looks a lot like serotonin) works to mimic some of serotonin’s actions. That psilocybin does this, may explain why it may be useful in the treatment of depression.

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53 thoughts on “Help us treat depression!

  1. Hello, it is wonderful to learn (through the article in the Independent) that research into psychedelics is finally being allowed to proceed. The article mentions that you may be looking for more research subjects, and I would like to volunteer. I am a 60 year old woman in excellent health both mentally and physically. I am a writer and artist (see my website), and also trained as a psychospiritual psychotherapist. I took LSD often during the sixties and always loved it. I never had a “bad trip”. I attribute this to my lack of fear, and my openness to inner exploration. I credit LSD with instilling in me a life-long interest in consciousness. I discovered that, uniquely among my fellow trippers, I had the ability to step somewhat out of the trip when necessary, returning when whatever situation in the outer world that had required my attention had been dealt with. I haven’t tripped since good quality, pure LSD became hard to obtain in the early seventies, but have always hoped to. I thank you for your attention, and hope that you will consider me as a potential research subject.

  2. Hi

    Whilst I had been aware of David Nutt’s interest in the therapeutic uses of psychedelics, it was only in reading today’s Independent (Sunday 17 August 2014) that I became aware of Dr. Carhart-Harris’ research.

    I am a 58 year old man who has suffered severe depression, and struggled with an addiction to alcohol, for most of my adult life. I have also, at various times since my mid-teens, been a recreational poly-drug user.

    Having avoided psychedelics during most of that time, due to some frightening experiences in my youth, I exploited the legality of mushrooms in the early 2000’s to experiment again. In the recreational sense, this proved highly enjoyable. It also proved to be a period of relative happiness in a long period of severe depression. I didn’t put the two together.

    In the last two years I have been lucky enough to have come upon a regular supply of extremely high quality liquid LSD, and have developed a regimen of taking a dose every three-to-four weeks. Aside from its undeniable pleasures in the recreational sense, its effect on my psychological well-being have been startling: I have been on a bare-minimum maintenance dosage of my prescribed anti-depressant (citalopram) for the last 18 months. Whilst still drinking, my alcohol consumption has dropped to what most would recognise as moderate drinking. My levels of anxiety have plummeted, despite some stressful work and domestic events, and whilst I can be, like everyone, unhappy on occasion, I have been free of my previously crippling depression for the longest period in the last 25 years and can not remember a time when I have felt so comfortable in my own skin.

    I was fascinated to read the interview with Dr. Carhart-Harris in today’s Independent, and would be interested in being kept abreast of his ongoing research. Please let me know of any plans you may have for crowd-funding ongoing research, and do not hesitate to contact me if you have any further questions as to my personal experiences.

    best regards

    Mark Pringle (London W9)

  3. I read in the article in the Independent that you are looking for more female subjects for your study. I’m a fifty-five year old female of Irish American heritage. I have used LSD many times in my teens (the good stuff from a chemist in Berkeley, Cali.) as well as psylocybin and MDMA later in my twenties and thirties. I haven’t used any drugs since about the year 2001 and have not consumed any alcohol since 1992. I began to suffer from sever depression in 2004 and am taking fluoxetine for it. I wholeheartedly support your efforts to find a way to help depression, it truly is debilitating. I can’t contribute financially but I could offer myself as a subject of study, if that seems appropriate. I would like to read more about how you see psylocybin helping with depression, can you email me some articles, or a URL? Thanks! Look forward to hearing from you. And congratulations on you bravery for bringing these drugs back into the realm of serious scientific study.

  4. I read about this study with growing enthusiasm and am also interested in discovering how/if I can contribute to this research. I am a 35 year old woman in London who has battled depression/anxiety since my early teens, and in those years in-between have been put on pretty much every prescribed drugs and gone through numerous therapy sessions to no avail. I have experience of using hallucinogens (LSD/psylocybin) both recreationally and, later on, as an aid to self-therapy to try and break the chains of depression together with music/art which I found incredibly moving and revealing and, quite honestly, more helpful than any structured therapy session. I am very keen on to being able to contribute to this research in any way, as this is something that could potentially provide great help for me personally.

  5. GREAT article in the Independent today (17th August 2014).

    Since 2012 I have been working in Cornwall to set up a network of support for people who have/are suffering with POM (Prescription Only Medication) and OTC (Over the Counter) drug dependency. It is a socially hidden dependency because of the ‘legal, safe and therefore effective’ perception that leads people to misguided confidence in the POM or OTC drugs they take.

    For those with depression, for example, blind faith can lead to feelings of despair when they realise the anti-depressants are not working. Similarly, I have spoken to people who have taken anti-depressants for decades and when asked are not sure why but are simply too afraid of what may happen if they stopped them.

    For me, the use of drugs in this way becomes a catalyst for pacifying the user– not for ensuring they have a fulfilling life, and there has to be more research to ascertain if there are alternative options that can provide long-lasting benefits. Reading Mark Pringles post on here is very interesting!

    I see a definite cycle of mental health (physical too) treated (often with long term use) with perfectly legal medication that does not have prolonged success for recovery, and in fact can (and often does) create or reinforce further issues with addiction.

    Whilst I personally feel that replacing an addictive substance with another addictive substance (albeit a ‘safer’ one) does not constitute recovery; your work and that of others before this research definitely appears to be going in the right direction.

    As we continue to lose the worldwide battle against licit and illicit use of drugs and the treatment of mental illness, we should be investigating all potential avenues that could lead to better management of both. I am not naive in overlooking the potential risk of LSD use, psychosis is a definite issue, but learning how to utilise drugs like Psilocybin, in therapeutic doses can only be positive.

    I believe strongly in what you propose and are trying to achieve. I am happy to support the research in any way that I am able. Please contact me with any specific requests.

    Kez

  6. Fascinating Indy interview. This kind of research is so overdue. I started taking LSD recreationally in the late 60’s when I was around 12 years old. With a couple of breaks, I continued to take it virtually every month until aged 17. It was the only recreational drug I used. I tried cannabis but found it to be a waste of my time and money compared to the profoundly stimulating effects of LSD. Likewise alcohol conferred no pleasure. Although there were a few instances of taking it with friends I far preferred to absorb it whilst alone. Cycling around Kent or listening to music were my favourite activities whilst “tripping”. I have often thought how tripping would effect me as an older man. However, the corruption of street drugs (partly why I stopped taking LSD) has deterred me from trying to obtain some. With this regard I’d like to offer myself as a potential candidate for the continuance of your research. Though not a drinker, my life experiences have been as coloured and chequered as the next persons.

    I hope your research bears the fruits many of us who have experienced LSD have always believed this entheogen promised.

  7. I’ve just read through your article and visited the website and found it very informative. I am a 44 year old male living in West Yorkshire. I have suffered from severe periods of acute depression and anxiety for much of my adult life, leading to hospitilisation in 2013.

    I have been prescibed and tried many different anti-depressant medications, i am currently taking SNRI Venlafaxine which does not seem to work and has various side effects attached. I am also using vitamin therapy (Niacin, Vit C in large doses) more out of desperation than anything else. I have experienced psychedelics in the form of “magic mushrooms” many years ago and the experience was lets say very pleasurable.
    I would ask to be considered as a candidate for this research and offer myself for any future trials. Please contact me for any information and updates and i wish you and your team all the success in your research.

    Kind regards

    Toby

  8. I loved your article and I’ve long been interested in the effects of psychedelics on the brain, as well as the mind. I’ve watched documentaries and read about similar studies conducted on DMT, and I would really like to participate in your study. I’m interested in both expanding my consciousness, as well as contributing to the scientific understanding of these types of substances and their effect on the brain. Luckily I am in London for six months starting September, and I saw that you need more female participants. Please contact me on my email if you still need participants, I would love to help!
    I’m a 23 year old female, previous experience with psilocybin and 2C-I.

  9. Half of my family have had severe mental health problems managed by medication that keeps them ‘stable’ when I was a child my greatest fear was mental illness, I found mushrooms at the age of 14… LSD at 16…. I had years of happiness watching my children grow without the need to take drugs, I went to Amsterdam in June this year and can’t put into words the beautiful trip I had, it’s enough to say that I am laid here still feeling incredible bliss and happiness reminiscing…

  10. Hi there,
    After seeing Robin’s presentation at Secret Garden Party it was refreshing to just read the article printed in the Independent.

    I would be interested in finding out about any opportunities to offer myself as a volunteer.

    Thank you, Cristyn.

  11. fascinated by the recent piece in the Inde! If you are looking for female participants i would be interested to be a part of this amazing study to help this important work continue. I’m a 28 year old female based in London, mixed race. Never experienced LSD before. Happy to be contacted if you’d like to know more and will make a small donation to help otherwise!

  12. I would be very interested in volunteering for this research! I’m a 27 year old female & saw your talk at Secret Garden party and would love to help out in any way I can.

  13. This research is so necessary and common sense, I am so glad that this resource is again being investigated. LSD and magic mushrooms are the only drugs that I would recommend, but I do so actively. I have had great experiences on them in the past, and having recently been trying to get over depression and addiction I had been thinking acid would be beneficial. It does seem natural to make this connection. If you are looking for more female volunteers I would be happy to help.

  14. It is heart lifting to know that LSD is being studied & used again for the benefit of the world, many thanks to those who kept the Lantern lit for the study of psychedelics.

  15. I remarked to my therapist only a few months ago, that I wished I could be treated with therapeutic doses of LSD. Having been in and out of therapy for clinical depression and anxiety and on and off medication since I was fifteen, the closest to ‘truth’, and non-distorted thinking (despite the visuals) I’ve ever experienced has been on LSD, which I’ve taken on numerous occasions (but not in the last 18 years) never experiencing a ‘bad trip’.
    I am now in my late forties, female and still seeking the right treatment. I am keen to be considered as a candidate for any further trials/research. Thank you.

  16. I’d be happy to volunteer for this – I’m a 27 year old female living in Brighton. Sadly I don’t have any money to offer, but am spreading the word about your fantastic research.

    Keep it up!

  17. Hi I just read your article it mentions that you need more females! I will love to join the study. I am very happy that this is finally happening! Thanks

  18. Hi my name is Dominique Cuzzone and I am a very, very healthy 20 year old girl who has and still having her fair share of LSD experiences. I think what you’re doin is so right, and wonderful! I have literally never felt so intune with myself after each trip. Regardless if it be a bad trip, an uncomfortable one, or a wordscan even describe one. I always learn something special from each one. I have literally seen the transformation, I used to be very suicidal-depressed, until I started experimenting with my mind. Wether it be through psychdellics or mediation, you other spiritual healing activity. I go to many music festivals where these ideas and activitys are manifested by large numbers of people. I am interested in volunteering in your experiment, I have a very, very strong mentality and is capable of handeling this kind spiritscience. More information can be discussed in time <3

  19. I was interested to read that you would like more female volunteers for your study. Like Lilian above, I used LSD in the early 70’s, but strangely I never saw it as purely recreational, but rather more as a learning experience to expand my consciousness. Lately I’ve been exploring ayahuasca, psilocybin and 100% cacao as plant medicines. I just finished reading Rick Strassman’s book ‘The Spirit Molecule’ yesterday and I realise now how difficult it is now to conduct such studies into psychedelics. I feel they can be very beneficial, so I am glad you are somehow managing to do this study. Anyway, I live in London and I would love to take part in your study. You may contact me on the email provided here. Best wishes

  20. Based on my own experiences, if anything has the power to help restore mental wellbeing, calm and confidence, and potentially shatter addictions, it is carefully administered hallucinogens. I am a 41-year-old journalist and lecturer who, until recently, suffered from occasional but severe self-esteem issues, mood swings, stress and anger issues. Although i had tried hallucinogens – with caution, and in low doses – occasionally between the ages of 23-39, and had predominantly positive experiences, I had not really experimented with them regularly, until last year. Since having an enormous personal insight while on psilocybin, i have been using them with more regularity (fortnightly or monthly) and the affects have been fully positive. Self-esteem issues have largely disappeared, as have the mood swings, and i have gathered a much greater (perhaps more objective) perspective over my behaviours, stress and anger and feel like, almost, a new, calmer, less anxious person. I no longer use other drugs recreationally because I no longer wish to, nor feel a need to. I am in no doubt that both LSD and psycilocibin have contributed to this relatively rapid shift in mindset (as nothing else in my life has really changed), and if it can benefit others as it has me, I would willingly take part in any controlled research.
    Besides my own experiences, in the past I lived with a partner with severe mental health issues and drug addiction – who also, since experiencing one LSD trip, no longer uses any drugs.

  21. Hi,

    I have very little experiences with hallucinogens, though I tried ecstasy twice, LSD once, some mushroom in Peru, and once I ate cactus. They were great and “mind-awakening” experiences. I tried these things thanks to my then new partner who was already a regular but modest user of hallucinogens, and still is. I had been very skeptical of all drugs given the facts that my mother is a very conservative minded pharmacist who very effectively taught me that all drugs were “evil”. Then I happened to have a partner for 6 years with heroin addiction, and whose sobering up I assisted for those 6 years, and with success (He has been heroin free for the past 10 years). Then came my new partner who really insisted that hallucinogens were very different from heroin and whose self-esteem and calmness and stress handling techniques just seemed very OK, so i slowly began to believe him that not all drugs are necessarily evil. So I started experimenting with him a few years ago, very occasionally and with very low doses, but then I became pregnant and have been breast-feeding for the past 2 years, so I stopped using hallucinogens.
    But I was very happy to read the Independent article about your research and I would gladly take part in it, as my “secret” wish was always this, to be able to try these hallucinogens with control and supervision and with hallucinogens from safe sources.
    I dont think I suffer from depression, however, I did have depressive spells in my life as I could handle stress (e.g. relationship break-ups) very poorly when I was younger. And I can also say, as did the previous commenter, Jane, that I suffer from occasional but severe self-esteem issues, mood swings, stress and anger issues, and I really want to change this. My present partner keeps telling me that it was LSD that really helped him figure out himself and all his problems and how to handle stress.
    To cut it short, I would participate in any controlled research if it is possible in any way. I am a 39 year old female from Hungary, but I have lived in London (Greenwich borough) for 2,5 years now.
    Looking forward to hearing from you and more about this research.

  22. You have given me hope!
    I have gone through depression most of my life, although I have been able to hide this and delt with my thoughts with various substances or changes in my personal life I became over whelmed in the past 10 years, with severe anxiety and panic attacks with extreme thoughts. Only to be put on one drug to another and CBT therapy. Which left me in a no better place.
    My only escape from this dark place was MDNA until my husband asked me to try magic mushrooms. I then started to feel a peace but only for a short time!
    Recently I have tried LSD and have stopped the panic attacks and bad thoughts. I hope that this will continue.
    I hope that I could be able to help in the trials to help anyone like me.
    Regards

    Don’t stop the good work.
    Beverley.

  23. Do mushrooms help with addiction? In my experience yes they do, purely by accident I cured my addiction to alcohol with a handful of mushroom experiences in the first three years of sobriety, now, fourteen years later, and with the help of this article I’m beginning to understand how my interest in psychedelics is a route to understanding my/ the human condition. Escapism is a reaction to this reality, Hopefully this research will open up the debate sufficiently
    So that one day, reality will be something we don’t need to hide from, that enough people will be tuned in enough to teach others to do life better.

  24. I wish you success with raising the funds for this research. Perhaps you could consider making the donation process easier and perhaps more transparent by using a crowdfunding tool such as kickstarter? I tried to donate to Beckley but could not see how to specify that the donation was for the depression trial?

  25. Hi,

    Like everyone else who has commented so far I too think that this opportunity to explore psychedelics is both overdue but fantastic at the same time.

    Anything that enable us to further understand the mind and potentially assess new ways of treating/learning more about mental health illnesses is always a positive.

    As a 27 year old female who has experienced depression and anxiety I would love to know how I can physically be of use to this great project. Should you require any female volunteers do feel free to respond.

    Yasmina

  26. I’ve come to your site not having see the article in the Indie, I went out looking for safe alternatives to antidepressants such as seretonergical halucegens and schemes in the UK.

    I would be interested in engaging with your organisation / participating in research /fundraising and and contributing.

    I don’t feel like baring my soul on this forum, or to reveal my back story, but to say hello, and hope for a response from like minded souls wanting to assist others on our journey.

    1. I missed the independent article and guess I have probably missed the crest of this wave. I’d love to sign up to volunteer if you need a 24 year old with most of the baggage you see written in the comments.

      I thought I was alone in thinking that mind altering chemicals can help. I have given up with all the ones I’ve tried from the GP. This article gives me hope.

      Our planet will look after us – even if we don’t look after it.

      Lucy – I’d really like to talk to someone else.. No one I know understands, it could be that we could help eachother for the better.

  27. Hello my name is Dominick, and I have had 3 strokes, a pulmonary embolism, kidney failure and an open heart surgery when I was 24 due to birth defects . I think that it’s some kind of Guinness World Record. If you could only fathom what I have been through. Anyway for the most part I have made a full recovery. Except for a few things like mussel spasms, sensations on the pinky side of my left hand that travel up into my shoulder, some motor functions, speech and short term memory loss.

    In addition to all that, a few cool things came out of the craziness. My vision increased from 20/20 to 20/10, intuition/hindsight increased by at least 60%, and my favorite controllable lucid dreaming, also intense closed eye visuals of futuristic machinery and medical devices while I am awake! I believe that the brain is one of the most magnificent mystery that holds endless possibilities!

    I’m am now 30 and up until a few weeks ago I have only experimented with psilocybin mushrooms once as a teen. About a month ago I tried LSD by myself for the first time. The experience was like nothing I ever thought was possible! Since then I’ve noticed feeling returning to my hands and face something I haven’t felt in almost 6 years!

    I’m am truly a fan of your work and science in general, if there is anything I can do to help further your research please do not hesitate to ask.I am fully aware of the risks involved with research! But without it how can we learn and overcome major obstacles? My mother always told me I could do and accomplish anything if I put my mind to it, my father told me I would never amount to anything and my grandmother said if you ask you shall receive!

    Thank you very much for your time and good luck on future research.

    Dominick Rippolone

    P. S.
    Be safe and have a wonderful holiday, also, here is a little story that came from my trip. Enjoy 🙂

    The journey begins just as it might. lieing in weight, wait, waiting for the exact moment to be released at once, just to be consumed by the love, fear and happiness of the dreaded MichAnimal clock… Tic tock Tic tock…
    The journey begins beyond the wait, wait to long it may never come! You just mist me. You laugh now opening the wake of a ripple, it’s never enough, it truly never comes. Like the sounds you see or the colors you hear…
    Don’t stop melting. It keeps coming in forces, but it’s winding down in a spiritual spiral of hours. It then turns back up again into the neverending cigarette that keeps smoking, ashes falling from the tip of the joint into the floor.
    Is it over? It just might! Then again it just might be starting! That again the tree that won’t bend, the wall that crawls and refuses to breath or the water that won’t bubble. But you only get what you put in.
    As daylight brakes and the explosion of sunlight illuminates the ocean of grass rolling to a stop. Now putting everything back the way it began, lying in weight, wait, waiting….

  28. I am massively interested in the use of psychedelics in psychology, especially when it comes to helping people with the massively horrible condition of depression. Personally, I have never been lucky enough to experience true psychedelic drugs as its difficult to find any that don’t potentially have god knows what added. I have suffered from anger, stress and depression for many years, trying to work out my own problems by researching and trying different methods of psychology and psychological analysis , but finding out that psychedelics like LSD and others could help with that, i’d love to be a part of your research. Sadly i’m not exactly in a financial situation where I could donate money, but i’d love to be considered to take part in the research and help pave the way for more validity to a drug that clearly has the potential to help so many people on this planet that suffer on a daily basis with depression.
    please get in to contact with me if there’s anyway that I can be of service to you and your research. Thank you.

  29. Hello. I am a 52 year old woman who is on Prozac and would love to reprogram my brain. I think I am an excellent communicator and would be a perfect specimen for your study. I did Crappy LSD in the late 70s and early 80s. I had a bad trip where I cried and cried and cried “Talked” my way thru it. But I think it affected my whole being. I also think I “repress” hallucinations….
    Would love to advocate for depression cures. And believe in the power and effectiveness of psychedelics! so much good can come from research and development for tools to aide in self mastery
    I am in California, planning a trip to Ireland next Spring. Please contact me if you would like to discuss scanning my brain.

  30. Hi,
    I am nearly 40 and have suffered on and off with depression since I was a teenager. I have relentlessly sought different therapies/medicines over the years – yet I am still here on my journey to find a solution. I have been prescribed 3 different types of medication, tried counselling, CBT, Hypnotherapy, Mindfulness, Transcendental Meditation among other more natural remedies like St. John’s Wort & Evening Primrose etc. Some have helped, but none have offered a cure and my depression continues to emerge again & again.
    I am a Mum of two young boys and currently work full time with teenagers with Autism & Asperger’s Syndrome. I feel my depression puts me at an advantage to understand what others go through, but it is also so very difficult to manage and live with. Your findings on the brain imagery are very interesting as if I could describe how my depression makes me feel its ‘as if I cannot turn off my emotions and I feel everything’!!!! I find it a constant battle to keep my head above the water and often find myself emotionally exhausted trying to keep up this fight for such long periods of time. Although proud of how I have learned to cope and live with my depression it still saddens me to know that it is no way to live and I am determined to continue my journey to find a cure.
    Recently my husband has done some reading into Psilocybin and other natural psychedelics such as Ayahuasca. Through his interests he found much evidence into the positive effects that these chemicals can have on depression and hence my own interest.
    If your clinical trials are still taking place or you have more coming up in the future I would love to be considered as a subject to help with your research – please get in touch! I look forward to following your studies.
    Rachel

  31. This is fantastic to see! I’m a huge believer in psychedelics and their ability to heal mental issues. I had a severe characteropathy (NPD) for most of my life and through the use of ketamine, magic mushrooms and LSD i completely healed myself. It wasn’t pleasant inducing a NDE and traversing through the Bardo Thodol of the Tibetan book of the dead but it was the most liberating experience of my life and I will never be the same man that went into that last trip.
    Since then I have become a huge fan of Stan Grof and his work. Very powerful medicine these things.

  32. I am 27 and I suffered from depression until a few days ago but still have some issues as anxiety and negative thinking that makes me somehow to have social panic attacks and possibly stress from past trauma events such as earthquake victim and I don’t want to be a victim of my mind no more. I let go of a great deal of depression with the brew of sacred mother Ayahuasca.
    If wise, I would be honered to participate to a research.
    Thanks!

  33. I’d love nothing more than to be part of this amazing trial. I’m 26 and have suffered depression since I was 14.
    I also suffer EUBPD (emotional unstable borderline personality disorder) but depression hits me hard. I truly believe this could change my life.

  34. Dear Friends,
    If you, or someone you love is struggling with an addiction, or mental health issue, I implore you to read this. For over a decade of my life, I’ve devoted myself to helping people break free from addictions. I earned an excellent reputation for counseling the countless souls of some of Boston’s toughest city enclaves, such as Charlestown, Southie, Dorchester and Roxbury. Years later, I continued my healing work with the “high profiles” and anyone else who can afford a high end Malibu rehab at $60,000 a month. While I played a pivotal role in assisting to relinquish those dark shadows embedded in an individuals’ psyche, I still had to deal with my own.
    A few years back, after relapsing myself, I turned to shamanic natural medicines, as I literally thought I was not going to return from my own personal hell. For me, it took a few doses of Ayahuasca, as if that Amazonian vine was powerfully beckoning my soul as an invitation, seeming to have a consciousness and volition of its own. Throughout the journey, Mother Ayahuasca nurtured me and loved me, as if I was back in the womb.
    She reminded me of what many of us have forgotten, as I communicated telepathically with benign, loving beings, not of this denser earth realm. I was informed that our spiritual potential is unlimited, and that Earth, being at the bottom rung of more advanced civilizations, has the opportunity to evolve, but we forget and forget as we take on fears, and negative projections and destructive thought formations, from other sources, most pervasively the media; but even family members and friends who love us, or the stranger you briefly interact with in a store. We absorb energy like a sponge, and it is so imperative to shield yourself and cleanse.
    It’s all energy, it’s what we are and with that, our consciousness is attached, so yes, it is paramount that you raise your vibrations so to speak, tune in to a higher frequency, less dense, lighter, freer, some levity in your step, please. Why so important? Because we are a part of a collective consciousness, but there are countless humans who don’t get this, as they are fully invested in their own individuality. Bob Marely coined the phrase One Love. He was right. We are not only one, but we are equally connected to the biosphere in the way it breathes, nourishes and renews itself, consciously-the ebb and flow. Praise God or whatever your higher power may be, the next time a hummingbird flies within several feet from you. Know that it is all for you, the trees and flowers, plants, the oceans. All, one love, to enjoy, respect and heal from.
    Under the monitoring of a medical staff, I took the ibogaine, and Grandpa Ibogaine, came in as more of a male energy, and lovingly kicked my ass a bit, as I saw demonic -like faces, yet quickly realized that they were simply the darkness I allowed to enter my psyche after over thirty years of hard living, and over time they festered. The dark shadows, the stuff that gets you physically, mentally, emotionally, and spiritually sick; and so vital that it gets purged out of you, freeing your aura from negative energy attachment, because overtime that energy accumulates, make no doubt about it. They appeared as though to remind me that “Ha Ha, we’re still in you!” Ironically, I made a scary face back at them, and I can only imagine what the doctors and nurses were thinking as they were monitoring me, but those demons evaporated when I finally told them I loved them too.
    They knew they were done with me as I gave them back two things they have no guard against, fearlessness and love. On all my other psychedelic journeys, they’ve never reappeared. The very same dark entities, or energy that would tell me to put a shotgun in my mouth, cut my wrists, or if I don’t have the guts, pick up a drink, or a narcotic, after I’ve been doing so well. They would cheer me on during every relapse, go darker Bill, and go darker. And then they would vicariously feed off my anguish: the hit off the crack pipe, the Times Square X rated video arcades in my tweeked out twenties, with creepy men knocking on the door for sexual favors, the drug deal gone bad, or good, giving the beatings or taking them, that “harmless” first sip of a cranberry and vodka, carpet crawling for cocaine residue on the floor, a food binge, the call of the casino, anger, fear, woe is me. They loved it.
    The beauty of ibogaine was my life review. As though viewing an 8mm film behind my eyelids, I saw my parents getting married before I was born; sensing the romantic feelings they once had for one another, before their only child came along via C-section. Suddenly, the film cut to Yankee Stadium in 1977 with my Grandpa, when times were innocent, yet the stadium was filled with all Africans, wearing African garb, and I recall feeling, safe, and loved, as if I was part of them as well. Then the ibogaine brought the buzzing of bees in my ears. The plant, after all, is indigenous to West Central Africa. The scene then cut to me as a little boy running on the beach in Rhode Island, and I could hear the patter of my feet on the wet sand, years before that ominous dark seed began to sprout throughout the family dynamics, as my father, a pharmaceutical rep had his own inner shadows to deal with.
    There was no mistaking his eyes when they had him, like two dark piercing coals. Surely, the dark shadows were introduced to him by my alcoholic grandfather and whatever karmic laws that needed to be atoned for. I’ve found the baton can be passed to radiate light, or darkness. The next day after my ibogaine journey, a rebirth, as if I had the new born skin of a baby. I will never forget the doctor taking me up to the rooftop Jacuzzi overlooking Tijuana. “Doctor, doctor, don’t turn the jets on yet!” It was like my first bath, and when I looked up at the crisp blue sunny sky, another first. Being handed a coconut water, and a fresh bowl of papaya, like another first.
    The psilocybin mushroom I view as regular medicine that can be taken more frequently, but as it was intended to be taken, sacredly. No booze, no weed, just the mushroom. If you’re not experienced, I suggest embarking on your mushroom journey under the guidance of an open minded therapist, or shaman. It’s good medicine. Myself, I will ingest three-to six grams, and head out for the wilderness, lie on a rock, meditate and be open to what the mushroom breathes into my consciousness.
    The sacred mushroom will show me a different set of parents if you will, and they would remind me that my biological earth parents I have, served a purpose for my higher good, and that all those psychological and emotional tests were all a part of the process, and despite the difficulty, and pain, love them, honor them, for assisting me in where I am today, spiritually. I was told to not get so caught up in the titles, or the roles; and that they too have lived before and are on their own journey, and to respect that, thus lowering my expectations and allowing to love them for exactly who they are.
    I use to counsel quite a few men who were molested by priests when they were young boys in the Boston rape scandal. I would tell them they have a part to play in the resentment and they would want to jump over my desk and pummel me. I would say, “Hold it! Look at your veins, you have none! Look at the track marks on your arms! Your kid is crying for you, yet being looked after by your girlfriends’ parents! Because of this priest? Are you going to allow this? Set him free, understand he was spiritually sick, and don’t give him the power.
    I am not one who believes in shaming an addict, as they are already carrying enough, but sometimes, I would have to hammer the wakeup call home. “You might as well pick out your suit for your wake”. Afterwards, I would remind them of their potential and empower them to the best of my ability, often sharing a pathetic and humiliating story from my own addiction past. These sessions would usually end in laughter, as I’m a firm believer that humor is like Aloe Vera for the soul.
    The mushroom showed me sacred geometrical patterns and colors not seen by the naked eye, along with extraordinary palaces, heavenly cathedrals, and Mayan pyramids, ultimately sensing the divine energies which inhabit them, as they would say, “We want to show you more”, reminding me how we limit ourselves by constructing rigid modes of thinking. When Jesus stated, “In my Father’s house, there are many mansions.” I think I know exactly what he meant.
    My shaman who administered the 5-meo-dmt was a beautiful woman and before placing the ceremonial pipe to my lips, she stated it is an honor to serve you this medicine, and I will be here when you get back. The doctor I work for was meditating in the corner of the room, and his personal assistant was doing the same. When I exhaled the serum from the Sonoran Desert Toad, I died an egoic death and was released out of my body for over twenty minutes. I entered an ineffable world of beautiful colors, patterns, consciousness and spirit.
    Most profound was the absolute message of love like I have never experienced, along with the reminder to forgive yourself Bill, forgive yourself. Release all that no longer serves your higher good. When I came back, I felt vulnerable, as if the people in the room were able to see every dark, nook and cranny of my past. But, my shaman immediately said, “We all do and think things that we are ashamed of. Let it go. Forgive yourself, and then you can truly love yourself”.
    I share these experiences because they are available to you as well, as they should be to all who are willing, ready, and able to enlarge their spiritual life through the use of the natural medicines. How you go about reconnecting yourself to the sacred is entirely up to you. For some, such things as yoga or meditation will suffice. I have found that the medicines I have mentioned, have actually enhanced both of those practices, and has even given me a better appreciation towards the twelve step philosophy. It was AA cofounder, Bill Wilson, whose close friend, Dr. William Silkworth, stated in 1939, that a psychic change must occur at some point, or the addict is doomed. I believe this to be true. Ironically, the ghosts of all those clients whom I allowed myself to get so close to, and met an untimely demise due to suicide or overdose, no longer haunt me. In fact, on many of my psychedelic journeys, they stop by and say hi, with love, appreciation and letting me know they are okay. In conclusion, ask yourself, what if we were naturally creative, resourceful and whole all along? What if, we had simply forgotten?

  35. Hello,
    I am a 34 year old woman, have struggled with depressive episodes since the age of 15, and have been medicated with antidepressants continuously since the age of 16, I have undergone many therapeutic methods, but would be interested in volunteering with your trials for further insight. Please contact me on my email address for more info.

  36. Hello, I’m a 28 year old PhD student. My research interests include current drug policy and future international drug strategy.
    I’ve been struggling with anxiety and depression since my early teenage years and I’ve been through both CBT and psychotherapy.
    I would be very interested in volunteering with any current or future trials.
    Thank you.

  37. helloo, im 17 years old and i was disgnosed with major depression a couple years ago, at the moment i thought my life couldnt get any worse but as time went on, being a lab rat basically, changing medications all the time, i realized it wouldnt get better. being off of the meds has probably worsened my condition..leading to extremely bad anxiety. i sound like an idiot but when i discovered LSD it really did change my life,everytime im in the pits of hell looking for answers, i look for answers through the drug…and everytime, i end up thanking myself more just for it turning everything around. i would not be breathing anymore if i hadnt experimented with myself. im still to this day struggling, i dont want to be doing any illegal things in my life, and looking into these things ive come to the conclusion i would love to be apart of any type of research/experiments/studies, anything, even if its just my stories. this means so much to me and im honestly just looking to help FOR help..im reaching out trying to still hold on. i have nothing going for me in my life and multiple time this drug has called for my name. i know my life is supposed to be apart of something this great. i hope i dont sound like too big of an uneducated child/idiot.

  38. Hi there,

    Ive been going through cycles of anxiety at work and in life, which seem to be getting more pronounced as I get older. Im 27 and really want to conquer this before it conquers me so would love to help out with research.

    Elle

  39. I would be very interested in taking part of one of your studies for treatment of depression. I’m 39 been on 3 different antidepressants over the years since the age of 19.

  40. It makes perfect sense to me how on the one hand psilocybin can treat depression, but was on the other hand catastrophic for me. I didn’t know at the time of taking that I’m Bipolar. Anything that raises Serotonin or affects receptors in some way is a risk and contraindicated for someone with Bipolar. Anything from SSRIs to St John’s Wort to light therapy can trigger mania or similar mood disturbance in someone who’s Bipolar. So inversely if it can cause mania it’s very likely to be an effective treatment for depression in some people. I just wish they’d find something that’s more effective, with less life damaging side effects for Bipolar disorder and especially Bipolar deoressiob.

  41. Hi. I’ve suffered with depression for over 20 or more years? I think it may have began with a ‘bad trip’ when I was 17 ish with some dodgy LSD mixed in with the wrong company. I do remember having mushrooms a few years after with great company which was a very positive experience & still have fond memories of today. Having researched the subject thoroughly I’d be VERY interested in participating in any future studies you have planned.

  42. Hey there,
    Im a 26yo student looking for help with my moderate depression. I’ve tried lsd 7 years ago and it made me feel better. I would really appreciate if someone helps me out with my case. I feel like my world is crumbling and I have no interest in life, pls email me

  43. Hello,
    I am a 30-year-old woman from South-Eastern Europe who’s been struggling with depression and anxiety since early teens. I used to be a chain smoker for years, and I used to drink too much wine. Aside from very few times when I took weed and hash, I have never tried any drugs nor was I ever on antidepressants or any other medication.

    I’ve been doing a bit of yoga and meditation; I swim three times a week; I try to follow a healthy diet, and I make sure I get enough R&R. All those things together have almost entirely got me out of my depression, but I do still struggle with anxiety, although I believe I’ve gotten better at overcoming it.

    I would love to participate in a study like yours. Please do let me know if you could use me.

    Alex

  44. Hallo all,
    I suffer with mental illness’s but more predominantly scizophreinia and I find the occasional dose of LSD or mushrooms very therapeutic to my illness It gives me a release and re-wires my brain and is very exciteing to engage in aswell I wouldn’t recommend it for everybody with mental illness but for the vast majority I would strongly advise sufferers of mental health problems to employ this method of self medication and expand/express ones self into a new way of thinking and maybe get some kind of release from a ever present and destructive illness I hope this feedback is read and recived in a positive manner that can be used to help In the study of phycdelics in psychiatry
    Best wishes to all
    W.Wilkes

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