Equivalent effects of acute tryptophan depletion on REM sleep in ecstasy users and controls
This study sought to test the association between 3,4-methylenedioxymethamphetamine use, serotonergic function and sleep. Materials and methods Ambulatory polysomnography was used to measure three nights sleep in 12 ecstasy users and 12 controls after screening (no intervention), a tryptophan- free amino acid mixture (acute tryptophan depletion (ATD)) and a tryptophan-supplemented control mixture.
ATD significantly decreased rapid eye movement (REM) sleep onset latency, increased the amount of REM sleep and increased the amount of stage 2 sleep in the first 3 h of sleep. There was no difference between ecstasy users’ and controls’ sleep on the screening night or after ATD.
These findings imply that the ecstasy users had not suffered significant serotonergic damage as indexed by sleep.
Our videos describing different aspects of what we do.
Psychedelics: Lifting the veil | Robin Carhart-Harris | TEDxWarwick
Mendel Kaelen: Psychological & Neurophysiological Effects of Music in Combination with Psychedelics
Robin Carhart-Harris - Psychedelic drugs in science and medicine
Comeback of psychedelics in science and medicine: Robin Carhart Harris
Can Magic Mushrooms treat depression?- Robin Carhart-Harris at New Scientist Live 2017
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- on The administration of psilocybin to healthy hallucinogen experienced volunteers Hi Drew Thanks for sharing. What was your method?