Cause for a re- think on drug models of psychosis and other psychiatric disorders

Psychiatry’s next top model: cause for a re-think on drug models of psychosis and other psychiatric disorders RL Carhart-Harris, S Brugger, DJ Nutt and JM Stone Despite the widespread application of drug modelling in psychiatric research, the relative value of different models has never been formally compared in the same analysis. Here we compared the …

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The administration of psilocybin to healthy hallucinogen experienced volunteers

The administration of psilocybin to healthy,hallucinogen-experienced volunteers in a mock-functional magnetic resonance imaging environment: a preliminary investigation of tolerability This study sought to assess the tolerability of intravenously administered psilocybin in healthy, hallucinogen-experienced volunteers in a mock-magnetic resonance imaging environment as a preliminary stage to a controlled investigation using functional magnetic resonance imaging to explore …

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Neural correlates of the psychedelic state

Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin Psychedelic drugs have a long history of use in healing ceremonies, but despite renewed interest in their therapeutic potential, we continue to know very little about how they work in the brain. Here we used psilocybin, a classic psychedelic found in magic …

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Homological scaffolds of brain functional networks

Homological scaffolds of brain functional networks Networks, as efficient representations of complex systems, have appealed to scientists for a long time and now permeate many areas of science, including neuroimaging (Bullmore and Sporns 2009 Nat. Rev. Neurosci. 10, 186–198. (doi:10.1038/nrn2618)). Traditionally, the structure of complex networks has been studied through their statistical properties and metrics …

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A web based survey on mephedrone

A web-based survey on mephedrone Mephedrone (4-methylmethcathinone) is a substituted cathinone with stimulant properties. The popularity of mephedrone in the UK rose sharply in 2009 after it became seen as a legal, cheap and easily available alternative to MDMA (ecstasy). Adverse events associated with its use, including a series of alleged deaths, attracted media attention …

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LSD enhances suggestibility in healthy volunteers

LSD enhances suggestibility in healthy volunteers Lysergic acid diethylamide (LSD) has a history of use as a psychotherapeutic aid in the treatment of mood disorders and addiction, and it was also explored as an enhancer of mind control. Objectives The present study sought to test the effect of LSD on suggestibility in a modern research …

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User perceptions of the benefits and harms of hallucinogenic drug use

User perceptions of the benefits and harms of hallucinogenic drug use: A web-based questionnaire study   This study used a web-based questionnaire to investigate user perceptions of the benefits and harms of hallucinogenic drug use. Over 600 forms were submitted. Users were asked to comment on the acute and prolonged effects of different drugs and …

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Broadband Cortical Desynchronization Underlies Psychedelic State

Broadband Cortical Desynchronization Underlies the Human Psychedelic State   Psychedelic drugs produce profound changes in consciousness, but the underlying neurobiological mechanisms for this remain unclear. Spontaneous and induced oscillatory activity was recorded in healthy human participants with magnetoencephalography after intravenous infusion of psilocybin—prodrug of the nonselective serotonin 2A receptor agonist and classic psychedelic psilocin. Psilocybin …

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