Neural correlates of the LSD experience revealed by multimodal neuroimaging

Neural correlates of the LSD experience revealed by multimodal neuroimaging

Lysergic acid diethylamide (LSD) is the prototypical psychedelic drug, but its effects on the human brain have never been studied before with modern neuroimaging. Here, three complementary neuroimag-ing techniques: arterial spin labeling (ASL), blood oxygen level- dependent (BOLD) measures, and magnetoencephalography (MEG), implemented during resting state conditions, revealed marked changes in brain activity after LSD … Read more

Ecstasy users report different sleep to matched controls

Ecstasy users report different sleep to matched controls

Current and former ecstasy users report different sleep to matched controls: a web-based questionnaire study This study sought to test the association between ecstasy use and abnormal sleep. An anonymous web-based questionnaire containing questions on drug use and sleep was completed by 1035 individuals. From this large sample, a group of 89 ecstasy users were … Read more

Waves of the Unconscious: The Neurophysiology of Dreamlike Phenomena

Waves of the Unconscious: The Neurophysiology of Dreamlike  Phenomena

Waves of the Unconscious: The Neurophysiology of Dreamlike Phenomena and Its Implications for the Psychodynamic Model of the Mind This paper reviews scientific literature on four subjective states: the dream state, the dreamy state of temporal lobe epilepsy and temporal lobe stimulation, the acute psychotic state, and the psychedelic state. Evidence is cited showing that … Read more

Was it a vision or a waking dream?

Was it a vision or a waking dream?

Was it a vision or a waking dream? A commentary on Disrupting posterior cingulate connectivity disconnects consciousness from the external environment by Herbet, G., Lafargue, G., de Champfleur, N. M., Moritz-Gasser, S., le Bars, E., Bonnetblanc, F., et al. (2014). Neuropsychologia 56C, 239–244. doi: 10.1016/j.neuropsychologia.2014.01.020 Reminiscent of Wilder Penfield’s famous experiments, Neurologists in France have … Read more

How do hallucinogens work on the brain?

How do hallucinogens  work on the brain?

How do hallucinogens work on the brain? Robin Carhart-Harris, Mendel Kaelen and David Nutt consider a big question on several levels The ‘classic’ hallucinogens – such as LSD (derived from ergotamine found in ergot fungi), dimethyltryptamine (DMT, the major hallucinogenic component of ayahuasca) and psilocybin (from magic mushrooms) – possess a unique and arguably unrivalled … Read more

Spatial Dependencies between Large-Scale Brain Networks

Spatial Dependencies between Large-Scale Brain Networks

Spatial Dependencies between Large-Scale Brain Networks Functional neuroimaging reveals both increases (task-positive) and decreases (task-negative) in neural activation with many tasks. Many studies show a temporal relationship between task positive and task negative networks that is important for efficient cognitive functioning. Here we provide evidence for a spatial relationship between task positive and negative networks. … Read more